Does ApoE affect sleep quality in AD?

ApoE - AD.
Sleep deprivate - AD
ApoE - Sleep deprive - AD ???

Brain Stimulation Turns Paralyzed Rats into Walkers, Swimmer

Interesting experiments. Can work in human?

Gene dosage and manic-behavior

Duplication of a single gene causes mice to have seizures and display manic-like behaviour. But valproate, an anticonvulsant and mood-stabilizing drug commonly used to treat bipolar disorder and epilepsy can reversed the symptoms. This suggests valproate can also help some people with hyperactivity who do not respond to common treatments.

Brain boosting drug - Ritalin

Ritalin is most often prescribed to suffers of ADHD. But a handful of students in Singapore are also using it as a "brain booster" to give them an edge over their competitors.

Read the report in today (21 Oct 2013) Straits Times.

Ketamine lifts Depression.

Is ketamine acting as antidepressant?

My favourite note-taking software

Microsoft OneNote has been around for MANY years (before Evernote). It is free if you have MS Office. It gives you offline access to your note (when you are in the air or without connection) without having to pay subscription for premier privilege. You can use your finger (or stylus) to write and annotate during discussion.

LSM4213 Lecture 10 Sleep

News:

Jet lagging everyday

How sleep deprivation destroy you?

How to gamify the lessons?

The rationale of gamification in education?
Steps to develop educational games.

Strange that Pearson in US is interested in developing games for education but not here. Maybe selling books are more profitable.

Sleep clean up your brain

Sleep was found to be a way to dispose waste toxins accumulated during a hard day's thinking. Read the news.

LSM4213 Lecture 9

Primer reading:
SfN Brain Facts - Learning and Memory

TED Seminars:
Elizabeth Loftus: The fiction of memory
How to manually change a memory: Steve Ramirez and Xu Liu
Neil Burgess: How your brain tells you where you are

Microsoft Windows thru the years

Growing up with Windows. From Poly to Uni, to work... after a brief spin with Mac, I am back to Windows again.

http://news.cnet.com/8301-10805_3-57607810-75/microsofts-windows-8.1-arrives-a-look-back-and-ahead/

New Research Driven Trends in Teaching

Educators are looking to research about how kids learn to influence teaching practices and tools.

Lectures on YouTube

Michael Malone (Duke University)
The Art of Storytelling

Robert Sapolsky (Stanford University)
Are human just another primate?
Schizophrenia
The uniqueness of humans

Shelly Kagan (Yale University)
How to live given the certainty of death

Angela Ahrendts (Burberry / Apple)
The power of human energy.

New Drug Development Direction for Mental Disorders

Drug company Novartis reboots new research direction.

New role for BDNF.

BDNF, exercise and brain ageing.
http://news.sciencemag.org/biology/2013/10/how-exercise-beefs-brain

Protein misfolding inhibitor

Small molecule to stop protein misfolding?

Depression starts very young.

Depression starts before you know.
http://www.bbc.co.uk/news/health-24465624

LSM4213 Lecture 8 Mood disorders

Biopolar Disorders
http://www.youtube.com/watch?v=8Ki9dgG3P5M
http://www.youtube.com/watch?v=y91TkBanOKY

Depression
http://www.youtube.com/watch?v=i5rcPpk05hU
Ketamine acting as antidepressant?

Schizophrenia
http://www.youtube.com/watch?v=syjEN3peCJw
http://www.youtube.com/watch?v=f6CILJA110Y

Electro-therapy
http://www.youtube.com/watch?v=oEZrAGdZ1i8

LSM4213 Lecture 7

Primer video:
Refreshing your memory of protein folding, view the following short YouTube Videos.
http://www.youtube.com/watch?v=iaHHgEoa2c8
http://www.youtube.com/watch?v=fvBO3TqJ6FE
http://www.youtube.com/watch?v=swEc_sUVz5I

Readings:

Soto (2003) Nat Rev Neurosci 4:49-60.

Skovronsky et al (2006) Annu Rev Pathol 1:151-170.

Ross & Poirier (2004) Nat Med 10(Supl):S10-S17.

Dobson (2003) Nature 426:884-890.

LSM4213 Lecture 6a

Reading Primer:
Brain Facts on Parkinson disease

Videos:
Understanding Parkinson's disease
Parkinsonian Gait Demonstration
Stem cell therapy for PD
PD and Dopamine
Deep brain stimulation for PD

Journal Articles:
http://www.ncbi.nlm.nih.gov/pubmed/23161999
http://www.ncbi.nlm.nih.gov/pubmed/23019375
http://www.ncbi.nlm.nih.gov/pubmed/23363512
http://www.ncbi.nlm.nih.gov/pubmed/23950519

Seminars:
Cognition, Movement and Parkinson's Disease
Demystifying Medicine- Parkinson's Disease: from genetics to surgery
Inside the Parkinsonian Brain: Is Too Much Rhythm a Bad Thing?